// Applications
Optogenetics
Lambda fiber cannulae can be used to target large volumes of tissue. Taper optical properties allow to deliver light either to the full region of interest or sub-portions of it, depending on how light is launched into the fiber.
Sigma fibers offer further customization of light emission sites by nanopatterned metal masks realized on the taper surface.
// Applications
Fiber Photometry
Lambda fiber cannulae can collect light through the entire tapered surface. When site selective light delivery is used to excite functional fluorescence, multisite fiber photometry with a single fiber can be achieved.
// List of publications
Papers Featuring OptogeniX products
2021
- Dacre J, Colligan M, et al., “A cerebellar-thalamocortical pathway drives behavioral context-dependent movement initiation“, Neuron
- Robert B, Kimchi EY, et al., “A functional topography within the cholinergic basal forebrain for processing sensory cues associated with reward and punishment “, eLife
- Alvarado JS, Goffinet J, et al., “Neural dynamics underliying birdsong practice and performance“, Nature
- Lee J & Sabatini B, “Striatal indirect pathway mediates exploration via collicular competition“, Nature
- Drake RAR, Steel KAJ, “Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats” , eLife
- Hamilos AE, Spedicato G., et al., “Slowly evolving dopaminergic activity modulates the moment-to-moment probability of reward-related self-timed movements“, eLife
2020
- Cruz BF, Soarez S, et al., “Striatal circuits support broadly opponent aspects of action suppression and production” , BioRxiv
- Ito H, Sales A, et al., Probabilistic, spinally-gated control of bladder pressure and autonomous micturition by Barrington’s nucleus CRH neurons , eLife
- Lee J, Wang W, et al., “Anatomically segregated basal ganglia pathways allow parallel behavioral modulation“, Nature Neuroscience
- Vincis R, Chen K, et al., “Dynamic Representation of Taste-Related Decisions in the Gustatory Insular Cortex of Mice“, Current Biology
2019
- Hayat H, Regev N, et al., “Locus-coeruleus norepinephrine activity gates sensory-evoked awakenings from sleep“, Science Advances
- Fernandez-Lamo I, Gomez-Dominguez D, et al., “Proximodistal Organization of the CA2 Hippocampal Area“, Cell Rep
- Guo J, Sauerbrei B, et al., “Disrupting cortico-cerebellar communication impairs dexterity“, eLife
- Jackman SL, Chen CH, et al., “In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films“, J. Vis. Exp.
2018
- Fernandez DC, Fogerson PM, et al., “Light Affects Mood and Learning through Distinct Retina-Brain Pathways“, Cell